羥基取代之桂皮酸苯乙酯衍生物在化粧品美白應用之評估

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 39 期 (2013) > Item 310902800/28067

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標題:	羥基取代之桂皮酸苯乙酯衍生物在化粧品美白應用之評估 Evaluations on the Cosmetic Application of Hydroxyl Substituted 2-Phenylethylcinnamate Derivatives
作者:	施佩禎黃仲挺汪文忠楊朝成
貢獻者:	醫藥化學系化粧品科技研究所
關鍵字:	羥基桂皮酸苯乙酯衍生物自由基羥基抗氧化美白 Hydroxyl Substituted 2-Phenylethylcinnamate Derivatives free radical Hydroxyl Anti-oxidation whitening
日期:	2013-12
上傳時間:	2014-10-02 16:05:35 (UTC+8)
摘要:	本研究是以一系?羥基在?同位置與??取代的桂皮酸苯乙酯衍生物，進?下?測試：一、抑制? 胺酸?活性試驗，二、紫外線吸收測試，三、抑制MMPs 活性試驗，評估其在美白、防曬的效能及應用於化粧品上之可?性。從結果發現：對抑制?胺酸?的美白效果上，化合物3a/b、4a/b、8a/b 與?胺酸、Dopa 結構較為相似，具有很好的抑制效果。甲氧基取代羥基後增加吸收紫外線光譜的寬?與能?。在試驗上，4a/b、8a 對MMP-9 有抑制作用，代表在抗光?化上具有成效。故本實驗中合成的羥基取代之桂皮酸苯乙酯衍生物在應用於化粧品的美白、防曬功能上極具開發潛?。 This research is an examination of derivatives which differs in positions and numbers of hydroxyl groups on a 2-phenylethylcinnamate. It is progressed with the following tests: Frist, the tyrosinase inhibition test, second, the absorbent of the ultraviolet rays and third, MMPs inhibition test in order to evaluate the efficiency of whiting, sun-blocking and the potentiality of uses on cosmetics. Results show out that the result to whiting of the tyrosinase inhibition, the compounds 3a/b, 4a/b, 8a/b have similar structure with tyrosine and Dopa, they have strong inhibition to tyrosinase. It is also found when the compound is substituted by methoxyl, the absorption to ultraviolet increases. In the MMPs inhibition test, compounds 4a/b. 8a inhibits MMP-9, showing influences on anti-photoaging. In summary, the 2-phenylethylcinnamate derivatives that are substituted by hydroxyl has a large potential of the development of the efficiency of whiting and sun-blocking in cosmetics in the future.
關聯:	嘉南學報(科技類), n.39, pp.1-7
显示于类别:	[嘉南學報] 39 期 (2013) [食藥產業暨檢測科技系(含五專)] 期刊論文 [化妝品應用與管理系(所)] 期刊論文

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