利用9日齡肉雞，每隻感染自本省野外分離之耐Sulfad imethox ine ( 5.D.)球蟲 (E.tenella ) 20000個卵囊，於第四天飲水投給300 、 600及1200 ppm之S.D.，並於300、 600、 1200 ppm之分別添加 0.12. O.24及0.48%之Terephthalic Acid (TPA )以增加其藥效，同時拿市售抗球蟲藥品益禽S.D.作比較。結果發現本省已有急性鵝球蟲E. tenella確實對S.D.產生了耐藥性。 Sulfadimethoxine (S.D.) is known as a popular sulfa drug for treatment of coccidia in poultry. In this report the resistant strain against S.D. was separated and confirmed as E. tenella by etiological and morphological observation.
Even at 1,200 ppm level, the mortality of 9 days old artificial infected chicks was about 25%. The addition of 0.48% terephthalic acid was not effective for treatment at the same dose level.