Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27954
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    標題: Triptolide Ameliorates Autoimmune Diabetes and Prolongs Islet Graft Survival in Nonobese Diabetic Mice
    作者: Huang, Shing-Hwa
    Lin, Gu-Jiun
    Chu, Chi-Hong
    Yu, Jyh-Cherng
    Chen, Teng-Wei
    Chen, Yuan-Wu
    Chien, Ming-Wei
    Chu, Chin-Chen
    Sytwu, Huey-Kang
    貢獻者: 休閒保健管理系
    關鍵字: Triptolide
    Type 1 Diabetes
    Islet Transplantation
    Nod Mice
    Autoimmune Recurrence
    Allograft Rejection
    日期: 2013-04
    上傳時間: 2014-05-26 10:50:28 (UTC+8)
    出版者: Lippincott Williams & Wilkins
    摘要: Objectives: Triptolide (TPL) possesses profound immunosuppressive effects and has potential in allograft transplantation. We investigated whether TPL treatment prevents autoimmune diabetes in nonobese diabetic (NOD) mice and prolongs the survival of islet grafts against autoimmune attack or allograft rejection.Methods: Diabetic incidence was monitored in TPL-treated NOD mice. Nonobese diabetic or BALB/c islets were transplanted into diabetic recipients treated with TPL. Different T-cell subsets in grafts or spleen were analyzed. The proliferation, apoptosis, cytokines, and activities of AKT, NF kappa B, and caspases 3, 8, and 9 of T cells were determined.Results: Diabetic incidence was reduced and inflammatory cytokines were decreased in islets and spleen under TPL treatment. T-cell proliferation was reduced and the survival of syngeneic or allogeneic grafts was significantly increased in TPL-treated mice. The populations of CD4, CD8, CD4CD69, CD8CD69, and interferon-gamma-producing T cells in islet grafts and spleen were reduced. Triptolide treatment increased the apoptosis of T cells in the spleen of recipients. Levels of phosphorylated protein kinase B and phosphorylated inhibitor of kappa B in splenocytes were reduced and caspases 3, 8, and 9 were increased in TPL-treated mice.Conclusions: Triptolide treatment not only reduced the diabetic incidence in NOD mice but also prolonged the survival of syngeneic or allogeneic grafts.
    關聯: Pancreas, v.42 n.3, pp.442-451
    顯示於類別:[休閒保健管理系(所)] 期刊論文

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