Role for gender in colorectal cancer risk: a Taiwan population-based study

doi:10.1007/s00384-013-1647-3

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 醫務管理系(所) > 期刊論文 > Item 310902800/27920

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標題:	Role for gender in colorectal cancer risk: a Taiwan population-based study
作者:	Chou, Chia-Lin Weng, Shih-Feng Lin, Jen-Kou Chang, Shih-Ching
貢獻者:	醫務管理系
關鍵字:	Colorectal Cancer Gender Prognosis
日期:	2013-07
上傳時間:	2014-05-26 10:49:04 (UTC+8)
出版者:	Springer
摘要:	Gender differences in the prognosis of colorectal cancer (CRC) remain controversial. The aim of this study was to complete a comprehensive analysis of gender differences in CRC survival derived from population registries in Taiwan.We analyzed survival data for patients diagnosed with CRC between 1998 and 2005 derived from the Taiwan Cancer Registry database. During this time period, 65,113 patients were registered, and 62,060 patients were eligible. Gender differences in overall survival and cancer-specific survival were analyzed by use of the Kaplan-Meier method. We then modeled the risk in different genders by use of a multivariate proportional hazard (Cox) model adjusting for possible confounders of survival.The 5-year period overall and cancer-specific survivals were significantly higher in women than in men [51.84 % (95 % confidence interval (CI), 51.22-52.46) vs. 47.68 % (95 % CI, 47.14-48.22), log-rank p < 0.001; and 56.44 % (95 % CI, 55.82-57.07) vs. 53.47 % (95 % CI, 52.92-54.01), log-rank p < 0.001, respectively]. Subgroup analysis revealed higher overall and cancer-specific survivals in women between 50 and 80 years age and those with adenocarcinomas (p < 0.001). By use of Cox modeling, we noted a decreased hazard ratio (HR) for death from CRC in women compared with men (HR, 0.820-0.971), especially in the 50-80-year age group. All estimated HRs, after adjusting for age, tumor histology, and tumor site, had significant trends of a decreasing risk of death from CRC in women.Our findings suggest that overall and cancer-specific survival advantage was most evident in women between 50 and 80 years of age.
關聯:	International Journal of Colorectal Disease, v.28 n.7, pp.1001-1008
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