Role for gender in colorectal cancer risk: a Taiwan population-based study

doi:10.1007/s00384-013-1647-3

CNU IR > College of Smart Living > Dept. of Hospital and Health (including master's program) > Periodical Articles > Item 310902800/27920

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27920

Title:	Role for gender in colorectal cancer risk: a Taiwan population-based study
Authors:	Chou, Chia-Lin Weng, Shih-Feng Lin, Jen-Kou Chang, Shih-Ching
Contributors:	醫務管理系
Keywords:	Colorectal Cancer Gender Prognosis
Date:	2013-07
Issue Date:	2014-05-26 10:49:04 (UTC+8)
Publisher:	Springer
Abstract:	Gender differences in the prognosis of colorectal cancer (CRC) remain controversial. The aim of this study was to complete a comprehensive analysis of gender differences in CRC survival derived from population registries in Taiwan.We analyzed survival data for patients diagnosed with CRC between 1998 and 2005 derived from the Taiwan Cancer Registry database. During this time period, 65,113 patients were registered, and 62,060 patients were eligible. Gender differences in overall survival and cancer-specific survival were analyzed by use of the Kaplan-Meier method. We then modeled the risk in different genders by use of a multivariate proportional hazard (Cox) model adjusting for possible confounders of survival.The 5-year period overall and cancer-specific survivals were significantly higher in women than in men [51.84 % (95 % confidence interval (CI), 51.22-52.46) vs. 47.68 % (95 % CI, 47.14-48.22), log-rank p < 0.001; and 56.44 % (95 % CI, 55.82-57.07) vs. 53.47 % (95 % CI, 52.92-54.01), log-rank p < 0.001, respectively]. Subgroup analysis revealed higher overall and cancer-specific survivals in women between 50 and 80 years age and those with adenocarcinomas (p < 0.001). By use of Cox modeling, we noted a decreased hazard ratio (HR) for death from CRC in women compared with men (HR, 0.820-0.971), especially in the 50-80-year age group. All estimated HRs, after adjusting for age, tumor histology, and tumor site, had significant trends of a decreasing risk of death from CRC in women.Our findings suggest that overall and cancer-specific survival advantage was most evident in women between 50 and 80 years of age.
Relation:	International Journal of Colorectal Disease, v.28 n.7, pp.1001-1008
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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