Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27906
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    標題: Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer
    作者: Chiu, Hui-Wen
    Chen, Mei-Huei
    Fang, Wen-Hung
    Hung, Ching-Ming
    Chen, Yen-Lin
    Wu, Ming-Der
    Yuan, Gwo-Fang
    Wu, Ming-Jiuan
    Wang, Ying-Jan
    貢獻者: 生物科技系
    關鍵字: Monascus
    Androgenetic Alopecia
    Benign Prostate Hyperplasia
    Prostate Cancer
    日期: 2013-05
    上傳時間: 2014-05-26 10:48:29 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen. related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone-induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.
    關聯: Journal of Agricultural And Food Chemistry, v.61 n.18, pp.4379-4386
    顯示於類別:[生物科技系(所)] 期刊論文

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