Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer

doi:10.1021/jf400873w

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/27906

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27906

Title:	Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer
Authors:	Chiu, Hui-Wen Chen, Mei-Huei Fang, Wen-Hung Hung, Ching-Ming Chen, Yen-Lin Wu, Ming-Der Yuan, Gwo-Fang Wu, Ming-Jiuan Wang, Ying-Jan
Contributors:	生物科技系
Keywords:	Monascus Androgenetic Alopecia Benign Prostate Hyperplasia Prostate Cancer
Date:	2013-05
Issue Date:	2014-05-26 10:48:29 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen. related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone-induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.
Relation:	Journal of Agricultural And Food Chemistry, v.61 n.18, pp.4379-4386
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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