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| 標題: | Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer |
| 作者: | Chiu, Hui-Wen
Chen, Mei-Huei
Fang, Wen-Hung
Hung, Ching-Ming
Chen, Yen-Lin
Wu, Ming-Der
Yuan, Gwo-Fang
Wu, Ming-Jiuan
Wang, Ying-Jan |
| 貢獻者: | 生物科技系 |
| 關鍵字: | Monascus
Androgenetic Alopecia
Benign Prostate Hyperplasia
Prostate Cancer |
| 日期: | 2013-05 |
| 上傳時間: | 2014-05-26 10:48:29 (UTC+8) |
| 出版者: | Amer Chemical Soc |
| 摘要: | Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen. related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone-induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases. |
| 關聯: | Journal of Agricultural And Food Chemistry, v.61 n.18, pp.4379-4386 |
| 顯示於類別: | [生物科技系(所)] 期刊論文
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