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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27902


    標題: Polyurethane-based drug delivery systems
    作者: Cherng, Jong Yuh
    Hou, Ting Yi
    Shih, Mei Fen
    Talsma, Herre
    Hennink, Wim E.
    貢獻者: 藥學系
    關鍵字: Polyurethane
    Isocyanate
    Biodegradability
    Biocompatibility
    Controlled Release
    Drug Delivery
    日期: 2013-06
    上傳時間: 2014-05-26 10:48:19 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Polyurethanes (PUs) are formed by a reaction between isocyanates and diols to yield polymers with urethane bonds (-NH-COO-) in their main chain. A great variety of building blocks is commercially available that allows the chemical and physical properties of PUs to be tailored to their target applications, particularly for the biomedical and pharmaceutical fields. This article reviews the synthesis and characterization of PUs and PU-copolymers, as well as their in vitro and in vivo biodegradability and biocompatibility. Particular emphasis is placed on the use of PUs for the controlled release of drugs and for the (targeted) delivery of biotherapeutics. (C) 2013 Elsevier B.V. All rights reserved.
    關聯: International Journal of Pharmaceutics, v.450 n.1-2, pp.145-162
    Appears in Collections:[藥學系(所)] 期刊論文

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