Polyurethane-based drug delivery systems

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標題:	Polyurethane-based drug delivery systems
作者:	Cherng, Jong Yuh Hou, Ting Yi Shih, Mei Fen Talsma, Herre Hennink, Wim E.
貢獻者:	藥學系
關鍵字:	Polyurethane Isocyanate Biodegradability Biocompatibility Controlled Release Drug Delivery
日期:	2013-06
上傳時間:	2014-05-26 10:48:19 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Polyurethanes (PUs) are formed by a reaction between isocyanates and diols to yield polymers with urethane bonds (-NH-COO-) in their main chain. A great variety of building blocks is commercially available that allows the chemical and physical properties of PUs to be tailored to their target applications, particularly for the biomedical and pharmaceutical fields. This article reviews the synthesis and characterization of PUs and PU-copolymers, as well as their in vitro and in vivo biodegradability and biocompatibility. Particular emphasis is placed on the use of PUs for the controlled release of drugs and for the (targeted) delivery of biotherapeutics. (C) 2013 Elsevier B.V. All rights reserved.
關聯:	International Journal of Pharmaceutics, v.450 n.1-2, pp.145-162
显示于类别:	[藥學系(所)] 期刊論文

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