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https://ir.cnu.edu.tw/handle/310902800/27884
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| 標題: | Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study |
| 作者: | Yeh, Poh-Shiow
Yang, Chun-Ming
Lin, Sheng-Hsiang
Wang, Wei-Ming
Chen, Po-Sheng
Chao, Ting-Hsing
Lin, Huey-Juan
Lin, Kao-Chang
Chang, Chia-Yu
Cheng, Tain-Junn
Li, Yi-Heng |
| 關鍵字: | Ischemic Stroke
High-Density Lipoprotein Cholesterol
Mortality |
| 日期: | 2013-06 |
| 上傳時間: | 2014-05-26 10:47:35 (UTC+8) |
| 出版者: | Elsevier Ireland Ltd |
| 摘要: | Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up.Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (<= 35 mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score > 6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p < 0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point.Conclusions: Low baseline HDL-C (<= 35 mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | Atherosclerosis, v.228 n.2, pp.472-477 |
| 顯示於類別: | [通識教育中心] 期刊論文
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