Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study

doi:10.1016/j.atherosclerosis.2013.03.015

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標題:	Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study
作者:	Yeh, Poh-Shiow Yang, Chun-Ming Lin, Sheng-Hsiang Wang, Wei-Ming Chen, Po-Sheng Chao, Ting-Hsing Lin, Huey-Juan Lin, Kao-Chang Chang, Chia-Yu Cheng, Tain-Junn Li, Yi-Heng
關鍵字:	Ischemic Stroke High-Density Lipoprotein Cholesterol Mortality
日期:	2013-06
上傳時間:	2014-05-26 10:47:35 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up.Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (<= 35 mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score > 6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p < 0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point.Conclusions: Low baseline HDL-C (<= 35 mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
關聯:	Atherosclerosis, v.228 n.2, pp.472-477
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