Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27884
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17760/20057 (89%)
造访人次 : 8077430      在线人数 : 310
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    標題: Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study
    作者: Yeh, Poh-Shiow
    Yang, Chun-Ming
    Lin, Sheng-Hsiang
    Wang, Wei-Ming
    Chen, Po-Sheng
    Chao, Ting-Hsing
    Lin, Huey-Juan
    Lin, Kao-Chang
    Chang, Chia-Yu
    Cheng, Tain-Junn
    Li, Yi-Heng
    關鍵字: Ischemic Stroke
    High-Density Lipoprotein Cholesterol
    日期: 2013-06
    上傳時間: 2014-05-26 10:47:35 (UTC+8)
    出版者: Elsevier Ireland Ltd
    摘要: Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up.Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (<= 35 mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score > 6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p < 0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point.Conclusions: Low baseline HDL-C (<= 35 mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
    關聯: Atherosclerosis, v.228 n.2, pp.472-477
    显示于类别:[通識教育中心] 期刊論文


    档案 描述 大小格式浏览次数
    310902800_27884.pdf405KbAdobe PDF470检视/开启

    在CNU IR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈