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| 標題: | In Vitro Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus |
| 作者: | Tang, Hung-Jen
Chen, Chi-Chung
Cheng, Kuo-Chen
Wu, Kuan-Ying
Lin, Yi-Chung
Zhang, Chun-Cheng
Weng, Tzu-Chieh
Yu, Wen-Liang
Chiu, Yu-Hsin
Toh, Han-Siong
Chiang, Shyh-Ren
Su, Bo An
Ko, Wen-Chien
Chuang, Yin-Ching |
| 貢獻者: | Chi Mei Med Ctr, Dept Med
Chi Mei Med Ctr, Dept Med Res
Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp
Natl Cheng Kung Univ, Inst Biotechnol, Med Coll & Hosp
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr |
| 關鍵字: | Field Gel-Electrophoresis
Antimicrobial Agents
Fusidic Acid
Infections
Tigecycline |
| 日期: | 2013-11 |
| 上傳時間: | 2014-05-26 10:46:42 (UTC+8) |
| 出版者: | Amer Soc Microbiology |
| 摘要: | To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections. |
| link: | http://dx.doi.org/10.1128/AAC.01236-13 |
| 關聯: | Antimicrobial Agents And Chemotherapy, v.57 n.11 pp.5717-5720 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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