In Vitro Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus

doi:10.1128/AAC.01236-13

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Title:	In Vitro Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus
Authors:	Tang, Hung-Jen Chen, Chi-Chung Cheng, Kuo-Chen Wu, Kuan-Ying Lin, Yi-Chung Zhang, Chun-Cheng Weng, Tzu-Chieh Yu, Wen-Liang Chiu, Yu-Hsin Toh, Han-Siong Chiang, Shyh-Ren Su, Bo An Ko, Wen-Chien Chuang, Yin-Ching
Contributors:	Chi Mei Med Ctr, Dept Med Chi Mei Med Ctr, Dept Med Res Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp Natl Cheng Kung Univ, Inst Biotechnol, Med Coll & Hosp Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Keywords:	Field Gel-Electrophoresis Antimicrobial Agents Fusidic Acid Infections Tigecycline
Date:	2013-11
Issue Date:	2014-05-26 10:46:42 (UTC+8)
Publisher:	Amer Soc Microbiology
Abstract:	To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.1128/AAC.01236-13
Relation:	Antimicrobial Agents And Chemotherapy, v.57 n.11 pp.5717-5720
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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