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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27829

    標題: Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor delta Expression in Rats
    作者: Chen, Zhih-Cherng
    Chen, Li-Jen
    Cheng, Juei-Tang
    貢獻者: 藥學系
    關鍵字: Fatty-Acid Oxidation
    Induced Cardiomyopathy
    Induced Cardiotoxicity
    Agonist Gw0742
    日期: 2013
    上傳時間: 2014-05-26 10:45:22 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: The present study investigates the changes of peroxisome proliferator-activated receptors delta (PPAR delta) expression and troponin phosphorylation in heart of rats which were treated with doxorubicin (DOX). Wistar rats which were treated with DOX according to a previous method. The protein levels of PPAR delta and troponin phosphorylation were measured using Western blot. The PPAR delta expression in heart was markedly reduced in DOX-treated rats showing a marked decrease in cardiac dP/dT and cardiac output. Also, cardiac troponin phosphorylation was lowered in DOX-treated rats. Meanwhile, combined treatment with the agonist of PPAR delta (GW0742) reversed the decrease of cardiac dP/dT and cardiac output in DOX-treated rats. Then, primary cultured cardiomyocytes from neonatal rats were used to measure the changes of calcium concentration in cells. In addition to both decrease of PPAR delta expression and troponin phosphorylation in neonatal cardiomyocytes by DOX, a marked decrease of calcium concentration was also observed. Our results suggest the mediation of cardiac PPAR delta in DOX-induced cardiotoxicity in rats. Thus, activation of PPAR delta may restore the expression of p-TnI and the cardiac performance in DOX-induced cardio toxicity in rats.
    關聯: Ppar Research v.2013, Article ID 456042
    Appears in Collections:[藥學系(所)] 期刊論文

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