Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27829
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27829


    Title: Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor delta Expression in Rats
    Authors: Chen, Zhih-Cherng
    Chen, Li-Jen
    Cheng, Juei-Tang
    Contributors: 藥學系
    Keywords: Fatty-Acid Oxidation
    Induced Cardiomyopathy
    Ppar-Delta
    Troponin-I
    Induced Cardiotoxicity
    Hodgkins-Disease
    Skeletal-Muscle
    Agonist Gw0742
    Heart-Failure
    Diabetic-Rats
    Date: 2013
    Issue Date: 2014-05-26 10:45:22 (UTC+8)
    Publisher: Hindawi Publishing Corporation
    Abstract: The present study investigates the changes of peroxisome proliferator-activated receptors delta (PPAR delta) expression and troponin phosphorylation in heart of rats which were treated with doxorubicin (DOX). Wistar rats which were treated with DOX according to a previous method. The protein levels of PPAR delta and troponin phosphorylation were measured using Western blot. The PPAR delta expression in heart was markedly reduced in DOX-treated rats showing a marked decrease in cardiac dP/dT and cardiac output. Also, cardiac troponin phosphorylation was lowered in DOX-treated rats. Meanwhile, combined treatment with the agonist of PPAR delta (GW0742) reversed the decrease of cardiac dP/dT and cardiac output in DOX-treated rats. Then, primary cultured cardiomyocytes from neonatal rats were used to measure the changes of calcium concentration in cells. In addition to both decrease of PPAR delta expression and troponin phosphorylation in neonatal cardiomyocytes by DOX, a marked decrease of calcium concentration was also observed. Our results suggest the mediation of cardiac PPAR delta in DOX-induced cardiotoxicity in rats. Thus, activation of PPAR delta may restore the expression of p-TnI and the cardiac performance in DOX-induced cardio toxicity in rats.
    Relation: Ppar Research v.2013, Article ID 456042
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

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