Brazilein from Caesalpinia sappan L. Antioxidant Inhibits Adipocyte Differentiation and Induces Apoptosis through Caspase-3 Activity and Anthelmintic Activities against Hymenolepis nana and Anisakis simplex

doi:10.1155/2013/864892

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標題:	Brazilein from Caesalpinia sappan L. Antioxidant Inhibits Adipocyte Differentiation and Induces Apoptosis through Caspase-3 Activity and Anthelmintic Activities against Hymenolepis nana and Anisakis simplex
作者:	Liang, Chia-Hua Chan, Leong-Perng Chou, Tzung-Han Chiang, Feng-Yu Yen, Chuan-Min Chen, Pin-Ju Ding, Hsiou-Yu Lin, Rong-Jyh
貢獻者:	化妝品應用與管理系
關鍵字:	High-Fat Diet Oxidative Stress Origanum-Vulgare Extract Acid Adipogenesis Antifungal Heartwood Allergy Obesity
日期:	2013
上傳時間:	2014-05-26 10:43:37 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	Brazilein, a natural, biologically active compound from Caesalpinia sappan L., has been shown to exhibit anti-inflammatory and antioxidant properties and to inhibit the growth of several cancer cells. This study verifies the antioxidant and antitumor characteristics of brazilein in skin cancer cells and is the first time to elucidate the inhibition mechanism of adipocyte differentiation, cestocidal activities against Hymenolepis nana, and reduction of spontaneous movement in Anisakis simplex. Brazilein exhibits an antioxidant capacity as well as the ability to scavenge DPPH center dot and ABTS(center dot+) free radicals and to inhibit lipid peroxidation. Brazilein inhibited intracellular lipid accumulation during adipocyte differentiation in 3T3-L1 cells and suppressed the induction of peroxisome proliferator-activated receptor gamma (PPAR gamma), the master regulator of adipogenesis, suggesting that brazilein presents the antiobesity effects. The toxic effects of brazilein were evaluated in terms of cell viability, induction of apoptosis, and the activity of caspase-3 in BCC cells. The inhibition of the growth of skin cancer cells (A431, BCC, and SCC25) by brazilein is greater than that of human skin malignant melanoma (A375) cells, mouse leukemic monocyte macrophage (RAW 264.7 cells), and noncancerous cells (HaCaT and BNLCL2 cells). The anthelmintic activities of brazilein against Hymenolepis nana are better than those of Anisakis simplex.
關聯:	Evidence-Based Complementary And Alternative Medicine, v.2013 Article ID 864892
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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