Brazilein from Caesalpinia sappan L. Antioxidant Inhibits Adipocyte Differentiation and Induces Apoptosis through Caspase-3 Activity and Anthelmintic Activities against Hymenolepis nana and Anisakis simplex

doi:10.1155/2013/864892

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/27786

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Title:	Brazilein from Caesalpinia sappan L. Antioxidant Inhibits Adipocyte Differentiation and Induces Apoptosis through Caspase-3 Activity and Anthelmintic Activities against Hymenolepis nana and Anisakis simplex
Authors:	Liang, Chia-Hua Chan, Leong-Perng Chou, Tzung-Han Chiang, Feng-Yu Yen, Chuan-Min Chen, Pin-Ju Ding, Hsiou-Yu Lin, Rong-Jyh
Contributors:	化妝品應用與管理系
Keywords:	High-Fat Diet Oxidative Stress Origanum-Vulgare Extract Acid Adipogenesis Antifungal Heartwood Allergy Obesity
Date:	2013
Issue Date:	2014-05-26 10:43:37 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	Brazilein, a natural, biologically active compound from Caesalpinia sappan L., has been shown to exhibit anti-inflammatory and antioxidant properties and to inhibit the growth of several cancer cells. This study verifies the antioxidant and antitumor characteristics of brazilein in skin cancer cells and is the first time to elucidate the inhibition mechanism of adipocyte differentiation, cestocidal activities against Hymenolepis nana, and reduction of spontaneous movement in Anisakis simplex. Brazilein exhibits an antioxidant capacity as well as the ability to scavenge DPPH center dot and ABTS(center dot+) free radicals and to inhibit lipid peroxidation. Brazilein inhibited intracellular lipid accumulation during adipocyte differentiation in 3T3-L1 cells and suppressed the induction of peroxisome proliferator-activated receptor gamma (PPAR gamma), the master regulator of adipogenesis, suggesting that brazilein presents the antiobesity effects. The toxic effects of brazilein were evaluated in terms of cell viability, induction of apoptosis, and the activity of caspase-3 in BCC cells. The inhibition of the growth of skin cancer cells (A431, BCC, and SCC25) by brazilein is greater than that of human skin malignant melanoma (A375) cells, mouse leukemic monocyte macrophage (RAW 264.7 cells), and noncancerous cells (HaCaT and BNLCL2 cells). The anthelmintic activities of brazilein against Hymenolepis nana are better than those of Anisakis simplex.
Relation:	Evidence-Based Complementary And Alternative Medicine, v.2013 Article ID 864892
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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