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| 標題: | Acid aspiration provokes the pneumonia caused by multidrug-resistant Acinetobacter baumannii in BALB/c mice |
| 作者: | Chiang, Shyh-Ren
Tang, Hung-Jen
Chen, Chung-Hua
Chen, Chi-Chung
Lee, Wen-Ying
Chang, Ping-Chin
Chiu, Yu-Hsin
Chuang, Yin-Ching |
| 貢獻者: | 藥學系 |
| 關鍵字: | Acid Aspiration
Multidrug-Resistant Acinetobacter Baumannii
Pneumonia
Mice
Lung Permeability |
| 日期: | 2013-06 |
| 上傳時間: | 2014-05-26 10:42:48 (UTC+8) |
| 出版者: | Elsevier Sci Ltd |
| 摘要: | Objective: To determine whether acid aspiration provokes the development of multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia in its host.Methods: Groups of mice were inoculated intratracheally (IT) with 50 mu l of 0.1 N HCl and 1 x 10(8) colony-forming units (CFU) Ab396 (A + Ab group), or 50 mu l of 0.1 N HCl and 20 mu l of 0.9% saline (A + S group), or 20 mu l of 0.9% saline and 1 x 10(8) CFU of Ab396 (S + Ab group), or 50 mu l of 0.9% saline and 20 mu l of 0.9% saline (S + S group). Cytokines, bacterial loads in the bronchoalveolar lavage fluid (BALF), lung permeability, histopathology of the lungs, and survival rates were evaluated.Results: Only the A + Ab mice developed extensive Ab396 pneumonia and had significantly elevated bacterial loads, increased lung leakage, and lower levels of tumor necrosis factor alpha (TNF-alpha) compared with the other three groups (p < 0.05, Mann-Whitney U-test). Moreover, a strong synergistic effect (p < 0.05, two-way analysis of variance) was observed between the acid induction and Ab396 infection, resulting in lung injury and an unfavorable survival outcome.Conclusions: Lung injury caused by acid aspiration provoked secondary MDRAB pneumonia; also synergistic effects between acid aspiration and Ab396 infection resulted in a detrimental outcome in the infected mice. (C) 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
| 關聯: | International Journal of Infectious Diseases, v.17 n.6 pp.E454-E460 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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