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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27716

    標題: Cytotoxic Effect of Eucalyptus citriodora Resin on Human Hepatoma HepG2 Cells
    作者: Shen, Kun-Hung
    Chen, Zong-Tsi
    Duh, Pin-Der
    貢獻者: 醫藥化學系
    關鍵字: Eucalyptus Citriodora Resin
    Hepatoma Cell Hepg2
    Antiproliferative Effect
    日期: 2012
    上傳時間: 2014-03-24 15:22:33 (UTC+8)
    出版者: World Scientific Publ Co Pte Ltd
    摘要: The aim of this study was to evaluate the antiproliferative effect of Eucalyptus citriodora resin (ECR) on human hepatoma HepG2 cells. The results from MTT assay and LDH leakage analysis showed that water extracts of ECR (WEECR) in the dose range of 0-500 mu g/ml displayed stronger cytotoxic effects on HepG2 cells than other organic solvent extracts of ECR. By flow cytometry analysis, WEECR slowed down the cell cycle at the G0/G1 phase after 24 h of incubation. Moreover, WEECR treatment induced an apoptotic response in HepG2 cells. WEECR-induced apoptosis was in association with the attenuation of mitochondrial transmembrane potentials (Delta psi(m)), increased Bax/Bcl-2 ratio and activation of caspase-3. In addition, WEECR contained high concentration of phenolics and flavonoids, which may be responsible for the potent cytotoxicity of WEECR on HepG2 cells. Taken together, WEECR may be a potent antihepatoma agent due to apoptosis in HepG2 cells.
    關聯: American Journal of Chinese Medicine, 40(2), 399-413
    Appears in Collections:[醫藥化學系 ] 期刊論文
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