Cytotoxic Effect of Eucalyptus citriodora Resin on Human Hepatoma HepG2 Cells

doi:10.1142/S0192415X12500310

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/27716

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27716

Title:	Cytotoxic Effect of Eucalyptus citriodora Resin on Human Hepatoma HepG2 Cells
Authors:	Shen, Kun-Hung Chen, Zong-Tsi Duh, Pin-Der
Contributors:	醫藥化學系食品科技系
Keywords:	Eucalyptus Citriodora Resin Hepatoma Cell Hepg2 Apoptosis Antiproliferative Effect
Date:	2012
Issue Date:	2014-03-24 15:22:33 (UTC+8)
Publisher:	World Scientific Publ Co Pte Ltd
Abstract:	The aim of this study was to evaluate the antiproliferative effect of Eucalyptus citriodora resin (ECR) on human hepatoma HepG2 cells. The results from MTT assay and LDH leakage analysis showed that water extracts of ECR (WEECR) in the dose range of 0-500 mu g/ml displayed stronger cytotoxic effects on HepG2 cells than other organic solvent extracts of ECR. By flow cytometry analysis, WEECR slowed down the cell cycle at the G0/G1 phase after 24 h of incubation. Moreover, WEECR treatment induced an apoptotic response in HepG2 cells. WEECR-induced apoptosis was in association with the attenuation of mitochondrial transmembrane potentials (Delta psi(m)), increased Bax/Bcl-2 ratio and activation of caspase-3. In addition, WEECR contained high concentration of phenolics and flavonoids, which may be responsible for the potent cytotoxicity of WEECR on HepG2 cells. Taken together, WEECR may be a potent antihepatoma agent due to apoptosis in HepG2 cells.
Relation:	American Journal of Chinese Medicine, 40(2), 399-413
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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