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| 標題: | Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis |
| 作者: | Wang, Bor-Sen
Lee, Chia Pu
Chen, Zong-Tsi
Yu, Hui Mei
Duh, Pin-Der |
| 貢獻者: | 食品科技系
生活應用與保健系
醫藥化學系
藥學系 |
| 關鍵字: | Cordyceps Militaris
Cordyceps Sinensis
Hepatoprotection
Oxidative Stress |
| 日期: | 2012-04 |
| 上傳時間: | 2014-03-21 16:16:55 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis on hepatotoxicity was investigated. Water extracts of C. militaris (CME) and water extracts of C. sinensis (CSE) protected the HepG2 cells against t-butyl hydroperoxide (t-BHP) induced oxidative injury. No significant differences were found between CME and CSE at 500 mu g/mL in ROS generation, GSH content, TSARS formation, Bcl-2/Bax ratio in t-BHP-induced HepG2 cells. The inhibitory effect of CME at 500 mu g/mL on caspase 3 activity in t-BHP-induced HepG2 cells was superior to CSE (500 mu g/mL). However, protective effect of CME on decreasing the mitochondria membrane potential in t-BHP-induced HepG2 cells was inferior to CSE. The hepatoprotective actions of CME and CSE in vitro may be related to maintenance of the normal redox status of cells. Taken together, our results suggest that CME could be a potentially useful source in substitution for CSE for preventing and treating hepatotoxicity. (C) 2012 Elsevier Ltd. All rights reserved. |
| 關聯: | Journal of Functional Foods, 4(2), 489-495 |
| 顯示於類別: | [ 食品科技系 ] 期刊論文
[生活保健科技系] 期刊論文
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