Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis

doi:10.1016/j.jff.2012.02.009

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/27664

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27664

Title:	Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis
Authors:	Wang, Bor-Sen Lee, Chia Pu Chen, Zong-Tsi Yu, Hui Mei Duh, Pin-Der
Contributors:	食品科技系生活應用與保健系醫藥化學系藥學系
Keywords:	Cordyceps Militaris Cordyceps Sinensis Hepatoprotection Oxidative Stress
Date:	2012-04
Issue Date:	2014-03-21 16:16:55 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis on hepatotoxicity was investigated. Water extracts of C. militaris (CME) and water extracts of C. sinensis (CSE) protected the HepG2 cells against t-butyl hydroperoxide (t-BHP) induced oxidative injury. No significant differences were found between CME and CSE at 500 mu g/mL in ROS generation, GSH content, TSARS formation, Bcl-2/Bax ratio in t-BHP-induced HepG2 cells. The inhibitory effect of CME at 500 mu g/mL on caspase 3 activity in t-BHP-induced HepG2 cells was superior to CSE (500 mu g/mL). However, protective effect of CME on decreasing the mitochondria membrane potential in t-BHP-induced HepG2 cells was inferior to CSE. The hepatoprotective actions of CME and CSE in vitro may be related to maintenance of the normal redox status of cells. Taken together, our results suggest that CME could be a potentially useful source in substitution for CSE for preventing and treating hepatotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.
Relation:	Journal of Functional Foods, 4(2), 489-495
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Life and Health Science] Periodical Articles

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