Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27651
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    標題: Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds
    作者: Sheu, Ming-Jyh
    Deng, Jeng-Shyan
    Huang, Ming-Hsing
    Liao, Jung-Chun
    Wu, Chieh-Hsi
    Huang, Shyh-Shyun
    Huang, Guan-Jhong
    Sheu, Ming-Jyh�
    貢獻者: 化妝品應用與管理系
    關鍵字: Dichondra Repens
    Antioxidant
    Anti-Inflammation
    No
    Tnf-Alpha
    Mda
    日期: 2012-05-15
    上傳時間: 2014-03-21 16:16:30 (UTC+8)
    出版者: Elsevier Sci Ltd
    摘要: Dichondra repens (DR) is the main constituent in herbal beverages and consumed daily as a nutrition supplement for the liver in Taiwan. This study investigated the antioxidant and anti-inflammatory effects of D. repens ethanol extract (EDR) and its reference compounds ex vivo and in vivo. Fingerprint chromatograms (from HPLC) indicated that EDR contained vanillin, umbelliferone and scopoletin. EDR was evaluated for its antioxidant effects and LPS-induced NO production in RAW 264.7 cells. EDR decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW 264.7 cells. In vivo anti-inflammatory activities of EDR were assessed in mouse paw oedema, induced by X-carrageenan (Carr). We investigate the antioxidant mechanism of EDR via studies of the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the oedematous paw. Serum NO and TNF-alpha were also measured. EDR exerts anti-inflammatory effects by suppressing TNF-alpha NO, and might be related to the decrement of the level of MDA in the oedema paw via increasing the activities of CAT, SOD and GPx in the liver. The results show that EDR might be a natural antioxidant and anti-inflammatory agent. (C) 2011 Elsevier Ltd. All rights reserved.
    關聯: Food Chemistry, 132(2), 1010-1018
    显示于类别:[化妝品應用與管理系(所)] 期刊論文

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