Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds

doi:10.1016/j.foodchem.2011.09.140

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/27651

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27651

標題:	Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds
作者:	Sheu, Ming-Jyh Deng, Jeng-Shyan Huang, Ming-Hsing Liao, Jung-Chun Wu, Chieh-Hsi Huang, Shyh-Shyun Huang, Guan-Jhong Sheu, Ming-Jyh�
貢獻者:	化妝品應用與管理系
關鍵字:	Dichondra Repens Antioxidant Anti-Inflammation No Tnf-Alpha Mda
日期:	2012-05-15
上傳時間:	2014-03-21 16:16:30 (UTC+8)
出版者:	Elsevier Sci Ltd
摘要:	Dichondra repens (DR) is the main constituent in herbal beverages and consumed daily as a nutrition supplement for the liver in Taiwan. This study investigated the antioxidant and anti-inflammatory effects of D. repens ethanol extract (EDR) and its reference compounds ex vivo and in vivo. Fingerprint chromatograms (from HPLC) indicated that EDR contained vanillin, umbelliferone and scopoletin. EDR was evaluated for its antioxidant effects and LPS-induced NO production in RAW 264.7 cells. EDR decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW 264.7 cells. In vivo anti-inflammatory activities of EDR were assessed in mouse paw oedema, induced by X-carrageenan (Carr). We investigate the antioxidant mechanism of EDR via studies of the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the oedematous paw. Serum NO and TNF-alpha were also measured. EDR exerts anti-inflammatory effects by suppressing TNF-alpha NO, and might be related to the decrement of the level of MDA in the oedema paw via increasing the activities of CAT, SOD and GPx in the liver. The results show that EDR might be a natural antioxidant and anti-inflammatory agent. (C) 2011 Elsevier Ltd. All rights reserved.
關聯:	Food Chemistry, 132(2), 1010-1018
Appears in Collections:	[化妝品應用與管理系(所)] 期刊論文

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