Promazine and chlorpromazine for prolonged spinal anesthesia in rats

doi:10.1016/j.neulet.2012.05.067

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/27608

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標題:	Promazine and chlorpromazine for prolonged spinal anesthesia in rats
作者:	Chen, Yu-Wen Chu, Chin-Chen Chen, Yu-Chung Kan, Chung-Dann Wang, Jhi-Joung
貢獻者:	休閒保健管理系
關鍵字:	Chlorpromazine Promazine Bupivacaine Spinal Blockade Motor Function Nociception
日期:	2012-07-19
上傳時間:	2014-03-21 16:15:06 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	Though promazine and chlorpromazine elicited cutaneous anesthesia, no study of spinal anesthesia with chlorpromazine and promazine has been reported. This study was to examine whether chlorpromazine and promazine produce spinal anesthesia. Using a rat model via intrathecal injection, we tested spinal blockades of motor function and nociception by promazine, chlorpromazine or bupivacaine, and so were dose-response studies and durations. We demonstrated that chlorpromazine and promazine elicited dose-dependent spinal blockades in motor function and nociception. On the 50% effective dose (ED50) basis, the rank of potency of these drugs was bupivacaine > promazine > chlorpromazine (P < 0.05 for the differences). On an equipotent basis (25% effective dose [ED25]. ED50, and ED75), the block duration caused by chlorpromazine or promazine was longer than that caused by the long-lasting local anesthetic bupivacaine (P<0.01 for the differences). Chlorpromazine and promazine, as well as bupivacaine, showed longer duration of sensory block than that of motor block. Our data reported that intrathecal promazine and chlorpromazine with a more sensory-selective action over motor blockade had less potent and longer-lasting spinal blockades when compared with bupivacaine. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
關聯:	Neuroscience Letters, 521(2), 115-118
顯示於類別:	[休閒保健管理系(所)] 期刊論文

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