Promazine and chlorpromazine for prolonged spinal anesthesia in rats

doi:10.1016/j.neulet.2012.05.067

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/27608

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27608

Title:	Promazine and chlorpromazine for prolonged spinal anesthesia in rats
Authors:	Chen, Yu-Wen Chu, Chin-Chen Chen, Yu-Chung Kan, Chung-Dann Wang, Jhi-Joung
Contributors:	休閒保健管理系
Keywords:	Chlorpromazine Promazine Bupivacaine Spinal Blockade Motor Function Nociception
Date:	2012-07-19
Issue Date:	2014-03-21 16:15:06 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	Though promazine and chlorpromazine elicited cutaneous anesthesia, no study of spinal anesthesia with chlorpromazine and promazine has been reported. This study was to examine whether chlorpromazine and promazine produce spinal anesthesia. Using a rat model via intrathecal injection, we tested spinal blockades of motor function and nociception by promazine, chlorpromazine or bupivacaine, and so were dose-response studies and durations. We demonstrated that chlorpromazine and promazine elicited dose-dependent spinal blockades in motor function and nociception. On the 50% effective dose (ED50) basis, the rank of potency of these drugs was bupivacaine > promazine > chlorpromazine (P < 0.05 for the differences). On an equipotent basis (25% effective dose [ED25]. ED50, and ED75), the block duration caused by chlorpromazine or promazine was longer than that caused by the long-lasting local anesthetic bupivacaine (P<0.01 for the differences). Chlorpromazine and promazine, as well as bupivacaine, showed longer duration of sensory block than that of motor block. Our data reported that intrathecal promazine and chlorpromazine with a more sensory-selective action over motor blockade had less potent and longer-lasting spinal blockades when compared with bupivacaine. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Relation:	Neuroscience Letters, 521(2), 115-118
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1795	View/Open

Loading...