Antiproliferative Activity and Apoptosis Induction of Eucalyptus Citriodora Resin and Its Major Bioactive Compound in Melanoma B16F10 Cells

doi:10.1021/jf301068z

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標題:	Antiproliferative Activity and Apoptosis Induction of Eucalyptus Citriodora Resin and Its Major Bioactive Compound in Melanoma B16F10 Cells
作者:	Duh, Pin-Der Chen, Zong-Tsi Lee, Shwu-Woan Lin, Tsuey-Pin Wang, Ya-Ting Yen, Wen-Jye Kuo, Ling-Feng Chu, Heuy-Ling
貢獻者:	食品科技系醫藥化學系保健營養系
關鍵字:	B16F10 Melanoma Cell Eucalyptus Citriodora Resin Oxidative Stress Apoptosis 6-[1-(P-Hydroxy-Phenyl)Ethyl]-7-O-Methyl Aromadendrin Antiproliferation
日期:	2012-08-15
上傳時間:	2014-03-21 16:14:25 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Antiproliferative activity and apoptosis induction of ethyl acetate of Eucalyptus citriodora resin (EAEER), and its major bioactive compound in melanoma B16F10 cells were investigated. 6-[1-(p-Hydroxy-phenyl)ethyl]-7-O-methyl aromadendrin (HEMA), a flavanol derivative, was isolated from EAEER and identified on the basis of its mass and NMR spectra. The results from MTT assay showed high antiproliferative effects of EAEER and HEMA on B16F10 cells. Moreover, EAEER- and HEMA-induced cell apoptosis was association with the decrease in the mitochondrial transmembrane potentials (Delta psi(m)), increase in Bax/Bcl-2 ratio, and activation of caspase-3. Cells treated with EAEER and HEMA generated intracellular reactive oxygen species (ROS) and nitric oxide (NO), indicating that ROS and RNS play important roles in the induction of apoptosis in B16F10 cells. Taken together, EAEER and its major bioactive compound, HEMA, inhibited the proliferation of B16F10 cells via apoptosis and may be a potential antimelanoma agent.
關聯:	Journal of Agricultural And Food Chemistry, 60(32), 7866-7872
顯示於類別:	[ 食品科技系 ] 期刊論文 [食藥產業暨檢測科技系(含五專)] 期刊論文 [保健營養系(所) ] 期刊論文

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