Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats

doi:10.1016/j.neulet.2012.07.036

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標題:	Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats
作者:	Chen, Yu-Wen Chu, Chin-Chen Chen, Yu-Chung Hung, Ching-Hsia Wang, Jhi-Joung
貢獻者:	休閒保健管理系
關鍵字:	Infiltrative Cutaneous Analgesia Propranolol Lidocaine Coadministration
日期:	2012-08-30
上傳時間:	2014-03-21 16:14:17 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	The purpose of this study was to investigate the cutaneous analgesic effect of propranolol and compare with a local anesthetic lidocaine. The potencies and equipotent doses were determined for infiltrative cutaneous analgesia on the rat back by determination of dose-response curves for propranolol and lidocaine. Propranolol as well as lidocaine elicited dose-dependent cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potency was propranolol (10.3 [8.9-11.9] mu mol kg(-1))> lidocaine (25.8 [24.3-27.8] mu Lmol kg(-1)) (P < 0.01). On equianalgesic doses (ED25, ED50, ED75), propranolol produced longer action of infiltrative cutaneous analgesia than lidocaine (P < 0.01). Coadministration of lidocaine (25.8 mu mol kg(-1)) and propranolol (1.7 mu mol kg(-1)) exhibited greater blockade and duration than lidocaine (25.8 mu mol kg(-1)) or propranolol (1.7 mu mol kg(-1)) alone. Propranolol displayed more potent and longer duration of action than lidocaine at producing cutaneous analgesia. Furthermore, propranolol may prove useful as an adjuvant for lidocaine in producing cutaneous analgesia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
關聯:	Neuroscience Letters, 524(2), 129-132
显示于类别:	[休閒保健管理系(所)] 期刊論文

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