Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats

doi:10.1016/j.neulet.2012.07.036

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/27583

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27583

Title:	Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats
Authors:	Chen, Yu-Wen Chu, Chin-Chen Chen, Yu-Chung Hung, Ching-Hsia Wang, Jhi-Joung
Contributors:	休閒保健管理系
Keywords:	Infiltrative Cutaneous Analgesia Propranolol Lidocaine Coadministration
Date:	2012-08-30
Issue Date:	2014-03-21 16:14:17 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	The purpose of this study was to investigate the cutaneous analgesic effect of propranolol and compare with a local anesthetic lidocaine. The potencies and equipotent doses were determined for infiltrative cutaneous analgesia on the rat back by determination of dose-response curves for propranolol and lidocaine. Propranolol as well as lidocaine elicited dose-dependent cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potency was propranolol (10.3 [8.9-11.9] mu mol kg(-1))> lidocaine (25.8 [24.3-27.8] mu Lmol kg(-1)) (P < 0.01). On equianalgesic doses (ED25, ED50, ED75), propranolol produced longer action of infiltrative cutaneous analgesia than lidocaine (P < 0.01). Coadministration of lidocaine (25.8 mu mol kg(-1)) and propranolol (1.7 mu mol kg(-1)) exhibited greater blockade and duration than lidocaine (25.8 mu mol kg(-1)) or propranolol (1.7 mu mol kg(-1)) alone. Propranolol displayed more potent and longer duration of action than lidocaine at producing cutaneous analgesia. Furthermore, propranolol may prove useful as an adjuvant for lidocaine in producing cutaneous analgesia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Relation:	Neuroscience Letters, 524(2), 129-132
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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