Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27569
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    標題: Effects of Captopril on Melanin Formation in B16 cells
    作者: Chu, Heuy-Ling
    Wang, Bor-Sen
    Chang, Li-Chen
    Chang, Lee-Wen
    Duh, Pin-Der
    貢獻者: 食品科技系
    生活應用與保健系
    藥學系
    關鍵字: Captopril
    Antityrosinase
    Reactive Oxygen Species
    Melanin Formation
    B16 Melanoma Cell
    日期: 2012-09
    上傳時間: 2014-03-21 16:13:48 (UTC+8)
    出版者: Food & Drug Adminstration
    摘要: The effect of captopril on melanin formation in B16 cells was investigated. In B16 intracellular model system, the effect of captopril on antityrosinase activity was found dose-dependent and correlated to its ability to suppress melanin formation. The copper chelation by captopril may in part be responsible for the inhibition of tyrosinase activity. Captopril also displayed a remarkable reducing ability and significantly inhibited ROS generation. Interestingly, captopril also significantly suppressed tyrosinase mRNA expression, as determined by reverse transcription-polymerase chain reaction (RT-PCR). Overall, the results showed that the protective effect of captopril makes it a potent inhibitor of melanin formation.
    關聯: Journal of Food And Drug Analysis, 20(3), 668-673
    显示于类别:[ 食品科技系 ] 期刊論文
    [生活應用與保健系] 期刊論文
    [藥學系(所)] 期刊論文

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