Effects of Captopril on Melanin Formation in B16 cells

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Title:	Effects of Captopril on Melanin Formation in B16 cells
Authors:	Chu, Heuy-Ling Wang, Bor-Sen Chang, Li-Chen Chang, Lee-Wen Duh, Pin-Der
Contributors:	食品科技系生活應用與保健系藥學系
Keywords:	Captopril Antityrosinase Reactive Oxygen Species Melanin Formation B16 Melanoma Cell
Date:	2012-09
Issue Date:	2014-03-21 16:13:48 (UTC+8)
Publisher:	Food & Drug Adminstration
Abstract:	The effect of captopril on melanin formation in B16 cells was investigated. In B16 intracellular model system, the effect of captopril on antityrosinase activity was found dose-dependent and correlated to its ability to suppress melanin formation. The copper chelation by captopril may in part be responsible for the inhibition of tyrosinase activity. Captopril also displayed a remarkable reducing ability and significantly inhibited ROS generation. Interestingly, captopril also significantly suppressed tyrosinase mRNA expression, as determined by reverse transcription-polymerase chain reaction (RT-PCR). Overall, the results showed that the protective effect of captopril makes it a potent inhibitor of melanin formation.
Relation:	Journal of Food And Drug Analysis, 20(3), 668-673
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Life and Health Science] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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