Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27569
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    Title: Effects of Captopril on Melanin Formation in B16 cells
    Authors: Chu, Heuy-Ling
    Wang, Bor-Sen
    Chang, Li-Chen
    Chang, Lee-Wen
    Duh, Pin-Der
    Contributors: 食品科技系
    生活應用與保健系
    藥學系
    Keywords: Captopril
    Antityrosinase
    Reactive Oxygen Species
    Melanin Formation
    B16 Melanoma Cell
    Date: 2012-09
    Issue Date: 2014-03-21 16:13:48 (UTC+8)
    Publisher: Food & Drug Adminstration
    Abstract: The effect of captopril on melanin formation in B16 cells was investigated. In B16 intracellular model system, the effect of captopril on antityrosinase activity was found dose-dependent and correlated to its ability to suppress melanin formation. The copper chelation by captopril may in part be responsible for the inhibition of tyrosinase activity. Captopril also displayed a remarkable reducing ability and significantly inhibited ROS generation. Interestingly, captopril also significantly suppressed tyrosinase mRNA expression, as determined by reverse transcription-polymerase chain reaction (RT-PCR). Overall, the results showed that the protective effect of captopril makes it a potent inhibitor of melanin formation.
    Relation: Journal of Food And Drug Analysis, 20(3), 668-673
    Appears in Collections:[Dept. of Food Science & Technology] Periodical Articles
    [Dept. of Applied Life Science and Health] Periodical Articles
    [Dept. of Pharmacy] Periodical Articles

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