Secondary prophylaxis treatment versus on-demand treatment for patients with

doi:10.1111/j.1365-2516.2010.02367.x

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/27074

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27074

標題:	Secondary prophylaxis treatment versus on-demand treatment for patients with
作者:	W.-S.LIOU T.-C.TU S.-N.CHENG T.-Y.CHOU C.-F.LEE T.-K.LIN M.-I.CHUNG T.-M.CHAM
貢獻者:	藥學系
關鍵字:	cost factor concentrate haemophilia A on-demand pharmacoeconomics prophylaxis
日期:	2011-01
上傳時間:	2013-10-25 15:33:50 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	This study compared secondary prophylaxis treatment with on-demand treatment for severe haemophilia A in Taiwan. Fifty patients from one medical centre were evaluated over a 5-year period. Differences in annual bleed rates and factor VIII (FVIII) utilization were assessed between patients receiving secondary prophylaxis and patients receiving FVIII concentrates on-demand. Results were then used as inputs in a pharmacoeconomic model to predict outcomes of future haemophilia therapy strategies in Taiwan. The median annual number of total bleeding episodes was significantly lower in the 13 (26%) patients who received secondary prophylaxis than in the 37 patients who received FVIII on-demand (7.76 vs. 31.91, P < 0.0001). The between-group difference in median annual factor VIII utilization was statistically significant (1824.41 IU kg−1 for the prophylaxis group and 1324.81 IU kg−1 for the on-demand group, P < 0.01). It was estimated that approximately $2 million (USD) per year would be added to the cost of treatment by having all severe haemophilia A patients in Taiwan receive secondary prophylaxis instead of on-demand therapy while 12 566 bleeding will be prevented. It is recommended that National Health Insurance officials utilize these data to evaluate the benefits of enhanced treatment strategies and before making substantial policy changes to haemophilia care in Taiwan.
關聯:	Haemophilia, 17(1), pp.45-54
Appears in Collections:	[藥學系(所)] 期刊論文

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