Secondary prophylaxis treatment versus on-demand treatment for patients with

doi:10.1111/j.1365-2516.2010.02367.x

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/27074

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27074

Title:	Secondary prophylaxis treatment versus on-demand treatment for patients with
Authors:	W.-S.LIOU T.-C.TU S.-N.CHENG T.-Y.CHOU C.-F.LEE T.-K.LIN M.-I.CHUNG T.-M.CHAM
Contributors:	藥學系
Keywords:	cost factor concentrate haemophilia A on-demand pharmacoeconomics prophylaxis
Date:	2011-01
Issue Date:	2013-10-25 15:33:50 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	This study compared secondary prophylaxis treatment with on-demand treatment for severe haemophilia A in Taiwan. Fifty patients from one medical centre were evaluated over a 5-year period. Differences in annual bleed rates and factor VIII (FVIII) utilization were assessed between patients receiving secondary prophylaxis and patients receiving FVIII concentrates on-demand. Results were then used as inputs in a pharmacoeconomic model to predict outcomes of future haemophilia therapy strategies in Taiwan. The median annual number of total bleeding episodes was significantly lower in the 13 (26%) patients who received secondary prophylaxis than in the 37 patients who received FVIII on-demand (7.76 vs. 31.91, P < 0.0001). The between-group difference in median annual factor VIII utilization was statistically significant (1824.41 IU kg−1 for the prophylaxis group and 1324.81 IU kg−1 for the on-demand group, P < 0.01). It was estimated that approximately $2 million (USD) per year would be added to the cost of treatment by having all severe haemophilia A patients in Taiwan receive secondary prophylaxis instead of on-demand therapy while 12 566 bleeding will be prevented. It is recommended that National Health Insurance officials utilize these data to evaluate the benefits of enhanced treatment strategies and before making substantial policy changes to haemophilia care in Taiwan.
Relation:	Haemophilia, 17(1), pp.45-54
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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