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https://ir.cnu.edu.tw/handle/310902800/26717
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| 標題: | Oxidative stress and pyrogenic fever pathogenesis |
| 作者: | Hou, Ching-Cheng
Lin, Hung
Chang, Ching-Ping
Huang, Wu-Tein
Lin, Mao-Tsun |
| 貢獻者: | 休閒保健管理系 |
| 關鍵字: | Pyrogen
Fever
Glutamate
Nitric oxide metabolite
Hydroxyl radical |
| 日期: | 2011-09 |
| 上傳時間: | 2013-06-21 16:52:29 (UTC+8) |
| 出版者: | Elsevier |
| 摘要: | The causative/regulatory connections between changes in tissue redox state and fever induction were investigated herein. Wherefore, LPS, the primary element of bacterial cell wall, in addition to inducing pro-inflammatory cytokines, activated macrophages and other leukocytes to secrete hydroxyl radical (OH), nitric oxide metabolites (NOx−), superoxide (O2) and other reactive oxygen/nitrogen species. Furthermore, inflammation response-associated hypoxia stimulated glutamate release, which caused excitotoxicity of cells by increasing extracellular Ca2+. Cytokines and glutamate in turn also triggered the release of large amounts of NOx−, OH, O2, and other radicals. Those reactive nitrogen species in turn caused cellular injury via the peroxidation of membrane lipids and oxidative damage of proteins and DNA. Glutamate, NOx−, OH and antioxidants participated in the pathogenesis and regulation of LPS- or cytokines-induced fever. In particular, to highlight the role of glutamate, prostaglandin E2, NOx− and OH generated in the hypothalamus during pyrogenic fever was attempted hereby. To find the link among the signaling with the glutamate, NOx− and OH/prostaglandin E2 in the hypothalamus during pyrogenic fever will be challenging and could now clinically suppress pyrogenic fever. |
| 關聯: | European Journal of Pharmacology 667(1-3), pp. 6-12 |
| 顯示於類別: | [休閒保健管理系(所)] 期刊論文
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