Oxidative stress and pyrogenic fever pathogenesis

doi:10.1016/j.ejphar.2011.05.075

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/26717

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/26717

Title:	Oxidative stress and pyrogenic fever pathogenesis
Authors:	Hou, Ching-Cheng Lin, Hung Chang, Ching-Ping Huang, Wu-Tein Lin, Mao-Tsun
Contributors:	休閒保健管理系
Keywords:	Pyrogen Fever Glutamate Nitric oxide metabolite Hydroxyl radical
Date:	2011-09
Issue Date:	2013-06-21 16:52:29 (UTC+8)
Publisher:	Elsevier
Abstract:	The causative/regulatory connections between changes in tissue redox state and fever induction were investigated herein. Wherefore, LPS, the primary element of bacterial cell wall, in addition to inducing pro-inflammatory cytokines, activated macrophages and other leukocytes to secrete hydroxyl radical (OH), nitric oxide metabolites (NOx−), superoxide (O2) and other reactive oxygen/nitrogen species. Furthermore, inflammation response-associated hypoxia stimulated glutamate release, which caused excitotoxicity of cells by increasing extracellular Ca2+. Cytokines and glutamate in turn also triggered the release of large amounts of NOx−, OH, O2, and other radicals. Those reactive nitrogen species in turn caused cellular injury via the peroxidation of membrane lipids and oxidative damage of proteins and DNA. Glutamate, NOx−, OH and antioxidants participated in the pathogenesis and regulation of LPS- or cytokines-induced fever. In particular, to highlight the role of glutamate, prostaglandin E2, NOx− and OH generated in the hypothalamus during pyrogenic fever was attempted hereby. To find the link among the signaling with the glutamate, NOx− and OH/prostaglandin E2 in the hypothalamus during pyrogenic fever will be challenging and could now clinically suppress pyrogenic fever.
Relation:	European Journal of Pharmacology 667(1-3), pp. 6-12
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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