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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26716


    標題: Isoflurane for spinal anesthesia in the rat
    作者: Hung, Ching-Hsia
    Chu, Chin-Chen
    Chen, Yu-Chung
    Chen, Yu-Wen
    Hong, Huei-Jyun
    Wang, Jhi-Joung
    貢獻者: 休閒保健管理系
    關鍵字: Intrathecal injection
    Isoflurane
    Lidocaine
    Spinal anesthesia
    日期: 2011-09
    上傳時間: 2013-06-21 16:52:28 (UTC+8)
    出版者: Elsevier
    摘要: Although isoflurane, a non-water soluble agent, has been known to block Na+ currents, its spinal anesthetic effect was not exposed. The aim of this experiment was to evaluate the local anesthetic effect of isoflurane in spinal anesthesia. After intrathecal injection of isoflurane on rats, the spinal anesthetic effect in motor function, proprioception and nociception were evaluated. Lidocaine, a common used local anesthetic, was used as control. Isoflurane acted like lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. Although isoflurane [27.6 (25.4–30.0)] had less potency when compared with lidocaine [1.0 (0.9–1.1)] (P < 0.001) in spinal anesthesia, it caused a much longer duration of spinal blockades than lidocaine at equianesthetic doses (P < 0.001). Our results showed that when compared with lidocaine, isoflurane produced a less potency but much longer duration in spinal anesthesia.
    關聯: neuroscience letters 501(3), pp. 138-142
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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