Isoflurane for spinal anesthesia in the rat

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Title:	Isoflurane for spinal anesthesia in the rat
Authors:	Hung, Ching-Hsia Chu, Chin-Chen Chen, Yu-Chung Chen, Yu-Wen Hong, Huei-Jyun Wang, Jhi-Joung
Contributors:	休閒保健管理系
Keywords:	Intrathecal injection Isoflurane Lidocaine Spinal anesthesia
Date:	2011-09
Issue Date:	2013-06-21 16:52:28 (UTC+8)
Publisher:	Elsevier
Abstract:	Although isoflurane, a non-water soluble agent, has been known to block Na+ currents, its spinal anesthetic effect was not exposed. The aim of this experiment was to evaluate the local anesthetic effect of isoflurane in spinal anesthesia. After intrathecal injection of isoflurane on rats, the spinal anesthetic effect in motor function, proprioception and nociception were evaluated. Lidocaine, a common used local anesthetic, was used as control. Isoflurane acted like lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. Although isoflurane [27.6 (25.4–30.0)] had less potency when compared with lidocaine [1.0 (0.9–1.1)] (P < 0.001) in spinal anesthesia, it caused a much longer duration of spinal blockades than lidocaine at equianesthetic doses (P < 0.001). Our results showed that when compared with lidocaine, isoflurane produced a less potency but much longer duration in spinal anesthesia.
Relation:	neuroscience letters 501(3), pp. 138-142
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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