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https://ir.cnu.edu.tw/handle/310902800/26712
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| 標題: | Class I antiarrhythmic drugs produced a spinal anesthetic effect in rats |
| 作者: | Huang, Kuo-Lun
Chu, Chin-Chen
Kuang-I.Cheng
Wang, Jhi-Joung
Yeh, Mou-Yung |
| 貢獻者: | 休閒保健管理系 |
| 關鍵字: | Antiarrhythmic
Quinidine
Mexiletine
Flecainide
Spinal anesthesia |
| 日期: | 2011-11 |
| 上傳時間: | 2013-06-21 16:52:21 (UTC+8) |
| 出版者: | Elsevier |
| 摘要: | Class I antiarrhythmic drugs are commonly used to treat cardiac rhythm disorders. Some of those drugs were recently reported to have both a cutaneous analgesic and a neural blocking effect. We evaluated whether these drugs have a spinal anesthetic effect. Three Class I antiarrhythmic drugs (class IA: quinidine, IB: mexiletine, and IC: flecainide) were tested. After they had been intrathecally injected in rats, the potencies and durations of these drugs on spinal anesthesia were recorded. Bupivacaine, a commonly used local anesthetic, and 5% dextrose solution were used as controls. Bupivacaine, flecainide, quinidine, and mexiletine produced a dose-related spinal blockade of motor function, proprioception, and nociception, but dextrose solution produced no spinal anesthetic effect. The descending order of potency was bupivacaine > flecainide > quinidine > mexiletine (p < 0.05 for all differences). On an equipotent basis, flecainide, quinidine, and bupivacaine produced similar durations of action, all of which were significantly longer than that of mexiletine (p < 0.05). In conclusion, intrathecal injections of Class I antiarrhythmic drugs produced a dose-related spinal anesthetic effect. These drugs may be potential candidates for developing new local anesthetics. |
| 關聯: | neuroscience letters 505(2), pp. 216-220 |
| 顯示於類別: | [休閒保健管理系(所)] 期刊論文
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