Class I antiarrhythmic drugs produced a spinal anesthetic effect in rats

doi:10.1016/j.neulet.2011.10.030

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Title:	Class I antiarrhythmic drugs produced a spinal anesthetic effect in rats
Authors:	Huang, Kuo-Lun Chu, Chin-Chen Kuang-I.Cheng Wang, Jhi-Joung Yeh, Mou-Yung
Contributors:	休閒保健管理系
Keywords:	Antiarrhythmic Quinidine Mexiletine Flecainide Spinal anesthesia
Date:	2011-11
Issue Date:	2013-06-21 16:52:21 (UTC+8)
Publisher:	Elsevier
Abstract:	Class I antiarrhythmic drugs are commonly used to treat cardiac rhythm disorders. Some of those drugs were recently reported to have both a cutaneous analgesic and a neural blocking effect. We evaluated whether these drugs have a spinal anesthetic effect. Three Class I antiarrhythmic drugs (class IA: quinidine, IB: mexiletine, and IC: flecainide) were tested. After they had been intrathecally injected in rats, the potencies and durations of these drugs on spinal anesthesia were recorded. Bupivacaine, a commonly used local anesthetic, and 5% dextrose solution were used as controls. Bupivacaine, flecainide, quinidine, and mexiletine produced a dose-related spinal blockade of motor function, proprioception, and nociception, but dextrose solution produced no spinal anesthetic effect. The descending order of potency was bupivacaine > flecainide > quinidine > mexiletine (p < 0.05 for all differences). On an equipotent basis, flecainide, quinidine, and bupivacaine produced similar durations of action, all of which were significantly longer than that of mexiletine (p < 0.05). In conclusion, intrathecal injections of Class I antiarrhythmic drugs produced a dose-related spinal anesthetic effect. These drugs may be potential candidates for developing new local anesthetics.
Relation:	neuroscience letters 505(2), pp. 216-220
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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