Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/26695
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    標題: Synthesis and Evaluation of Poly(hexamethylene-urethane) and PEG-Poly(hexamethylene-urethane) and TheirCholesteryl Oleyl Carbonate Composite for Human Blood Biocompatibility
    作者: Shih, Mei Fen
    Shau, Min Da
    Hsieh, Cheng Chih
    Cherng, Jong Yuh
    貢獻者: 生物科技系
    關鍵字: polymer
    cholesteryl oleyl carbonate
    platelet
    blood compatibility
    日期: 2011-12
    上傳時間: 2013-06-05 16:42:51 (UTC+8)
    摘要: Two new urethane-based acrylates (UAA and PEG-UAA) were synthesized as polymer blocks. The chemical composition of the two monomers was confirmed by IR and NMR. After cross-linking these blockers by radical polymerization, “hexamethylene PU” [poly(hexamethylene-urethane)] and “PEG-hexamethylene PU” [PEG-poly(hexa-methylene-urethane)] were obtained. The platelet adhesion and platelet activation of these polymers were evaluated in the presence of Platelet Rich Plasma (PRP) blood. The relative blood clotting indexes of the polymers were determined to measure their capability of reducing thrombogenicity. The hemolysis of red blood cells was also assessed to examine the haemocompatibility of the polymers. The hexamethylene PU and PEG-hexamethylene PU showed less platelet adhesion, platelet activation, blood clotting and hemolysis than a commercial PU (Tecoflex). The liquid crystal molecule, cholesteryl oleyl carbonate (COC), showed further improved biocompatibility to human blood, after COC was embedded in the PU polymers. PEG-hexamethylene PU + 10% COC demonstrated the best activity in reducing thrombogenicity and the best haemocompatibility. The inclusion of PEG segments into the PEG-UAA structure increased its hydrophilicity. The methylene bis(cyclohexyl) segments in Tecoflex PU decreased haemocompatibility. These observations are in good agreement with performed contact angle measurements. The PEG-hexamethylene PU loaded with COC might be a promising material for applications in bioengineering.
    關聯: molecules 16(10), pp.8181-8197
    显示于类别:[生物科技系(所)] 期刊論文

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