Synthesis and Evaluation of Poly(hexamethylene-urethane) and PEG-Poly(hexamethylene-urethane) and TheirCholesteryl Oleyl Carbonate Composite for Human Blood Biocompatibility

doi:10.3390/molecules16108181

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/26695

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/26695

Title:	Synthesis and Evaluation of Poly(hexamethylene-urethane) and PEG-Poly(hexamethylene-urethane) and TheirCholesteryl Oleyl Carbonate Composite for Human Blood Biocompatibility
Authors:	Shih, Mei Fen Shau, Min Da Hsieh, Cheng Chih Cherng, Jong Yuh
Contributors:	生物科技系
Keywords:	polymer cholesteryl oleyl carbonate platelet blood compatibility
Date:	2011-12
Issue Date:	2013-06-05 16:42:51 (UTC+8)
Abstract:	Two new urethane-based acrylates (UAA and PEG-UAA) were synthesized as polymer blocks. The chemical composition of the two monomers was confirmed by IR and NMR. After cross-linking these blockers by radical polymerization, “hexamethylene PU” [poly(hexamethylene-urethane)] and “PEG-hexamethylene PU” [PEG-poly(hexa-methylene-urethane)] were obtained. The platelet adhesion and platelet activation of these polymers were evaluated in the presence of Platelet Rich Plasma (PRP) blood. The relative blood clotting indexes of the polymers were determined to measure their capability of reducing thrombogenicity. The hemolysis of red blood cells was also assessed to examine the haemocompatibility of the polymers. The hexamethylene PU and PEG-hexamethylene PU showed less platelet adhesion, platelet activation, blood clotting and hemolysis than a commercial PU (Tecoflex). The liquid crystal molecule, cholesteryl oleyl carbonate (COC), showed further improved biocompatibility to human blood, after COC was embedded in the PU polymers. PEG-hexamethylene PU + 10% COC demonstrated the best activity in reducing thrombogenicity and the best haemocompatibility. The inclusion of PEG segments into the PEG-UAA structure increased its hydrophilicity. The methylene bis(cyclohexyl) segments in Tecoflex PU decreased haemocompatibility. These observations are in good agreement with performed contact angle measurements. The PEG-hexamethylene PU loaded with COC might be a promising material for applications in bioengineering.
Relation:	molecules 16(10), pp.8181-8197
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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