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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26666

    標題: Inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells
    作者: Ding, Hsiou-Yu
    Chang, Te-Sheng
    Chiang, Chien-Min
    Tai, Sorgan Shou-Ku
    貢獻者: 化粧品科技研究所
    日期: 2011-01
    上傳時間: 2013-06-03 15:52:48 (UTC+8)
    出版者: Soc Cosmetic Chemists
    摘要: The inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells was investigated. The results showed that the P. acidula extract (PAE) inhibited melanogenesis in 3-isobutyl-1-methylxanthin (IBMX)-stimulated B16 cells in a dose-dependent manner, with an IC50 value of 33.5 μg/ml. In addition, PAE also inhibited cellular tyrosinase activity. Moreover, western blot and real-time reverse transcriptase polymerase chain reaction (qRT-PCR) analyses respectively confirmed that PAE down-regulated levels of tyrosinase protein and its mRNA in IBMX-stimulated B16 cells. These results demonstrated that PAE inhibits melanogenesis of B16 cells by reducing tyrosinase gene expression. From the present study, PAE is proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation.
    關聯: Journal of cosmetic science 62(1), pp. 41-48
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文
    [生物科技系(所)] 期刊論文

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