Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/26666
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    Title: Inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells
    Authors: Ding, Hsiou-Yu
    Chang, Te-Sheng
    Chiang, Chien-Min
    Tai, Sorgan Shou-Ku
    Contributors: 化粧品科技研究所
    Date: 2011-01
    Issue Date: 2013-06-03 15:52:48 (UTC+8)
    Publisher: Soc Cosmetic Chemists
    Abstract: The inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells was investigated. The results showed that the P. acidula extract (PAE) inhibited melanogenesis in 3-isobutyl-1-methylxanthin (IBMX)-stimulated B16 cells in a dose-dependent manner, with an IC50 value of 33.5 μg/ml. In addition, PAE also inhibited cellular tyrosinase activity. Moreover, western blot and real-time reverse transcriptase polymerase chain reaction (qRT-PCR) analyses respectively confirmed that PAE down-regulated levels of tyrosinase protein and its mRNA in IBMX-stimulated B16 cells. These results demonstrated that PAE inhibits melanogenesis of B16 cells by reducing tyrosinase gene expression. From the present study, PAE is proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation.
    Relation: Journal of cosmetic science 62(1), pp. 41-48
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
    [Dept. of Biotechnology (including master's program)] Periodical Articles

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