Inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells

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Title:	Inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells
Authors:	Ding, Hsiou-Yu Chang, Te-Sheng Chiang, Chien-Min Tai, Sorgan Shou-Ku
Contributors:	化粧品科技研究所生物科技系(所)
Date:	2011-01
Issue Date:	2013-06-03 15:52:48 (UTC+8)
Publisher:	Soc Cosmetic Chemists
Abstract:	The inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells was investigated. The results showed that the P. acidula extract (PAE) inhibited melanogenesis in 3-isobutyl-1-methylxanthin (IBMX)-stimulated B16 cells in a dose-dependent manner, with an IC50 value of 33.5 μg/ml. In addition, PAE also inhibited cellular tyrosinase activity. Moreover, western blot and real-time reverse transcriptase polymerase chain reaction (qRT-PCR) analyses respectively confirmed that PAE down-regulated levels of tyrosinase protein and its mRNA in IBMX-stimulated B16 cells. These results demonstrated that PAE inhibits melanogenesis of B16 cells by reducing tyrosinase gene expression. From the present study, PAE is proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation.
Relation:	Journal of cosmetic science 62(1), pp. 41-48
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles [Dept. of Biotechnology (including master's program)] Periodical Articles

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