Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/26666
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17775/20116 (88%)
Visitors : 10207943      Online Users : 461
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26666


    Title: Inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells
    Authors: Ding, Hsiou-Yu
    Chang, Te-Sheng
    Chiang, Chien-Min
    Tai, Sorgan Shou-Ku
    Contributors: 化粧品科技研究所
    生物科技系(所)
    Date: 2011-01
    Issue Date: 2013-06-03 15:52:48 (UTC+8)
    Publisher: Soc Cosmetic Chemists
    Abstract: The inhibitory effect of a water extract from Pemphis acidula on melanogenesis in mouse B16 melanoma cells was investigated. The results showed that the P. acidula extract (PAE) inhibited melanogenesis in 3-isobutyl-1-methylxanthin (IBMX)-stimulated B16 cells in a dose-dependent manner, with an IC50 value of 33.5 μg/ml. In addition, PAE also inhibited cellular tyrosinase activity. Moreover, western blot and real-time reverse transcriptase polymerase chain reaction (qRT-PCR) analyses respectively confirmed that PAE down-regulated levels of tyrosinase protein and its mRNA in IBMX-stimulated B16 cells. These results demonstrated that PAE inhibits melanogenesis of B16 cells by reducing tyrosinase gene expression. From the present study, PAE is proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation.
    Relation: Journal of cosmetic science 62(1), pp. 41-48
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
    [Dept. of Biotechnology (including master's program)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML801View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback