Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/26663
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    標題: Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale
    作者: Lin, Victor Chia-Hsiang
    Ding, Hsiou-Yu
    Kuo, Shiou-Yi
    Chin, Ling-Wei
    Wu, Jiumn-Yih
    Chang, Te-Sheng
    貢獻者: 化粧品科技研究所
    關鍵字: B16 melanoma
    tyrosinase
    inhibition
    zebrafish
    melanogenesis
    Rheum officinale
    raspberry ketone
    日期: 2011-10
    上傳時間: 2013-06-03 15:52:45 (UTC+8)
    出版者: Mdpi Ag
    摘要: Melanogenesis inhibition by raspberry ketone (RK) from Rheum officinale was investigated both in vitro in cultivated murine B16 melanoma cells and in vivo in zebrafish and mice. In B16 cells, RK inhibited melanogenesis through a post-transcriptional regulation of tyrosinase gene expression, which resulted in down regulation of both cellular tyrosinase activity and the amount of tyrosinase protein, while the level of tyrosinase mRNA transcription was not affected. In zebrafish, RK also inhibited melanogenesis by reduction of tyrosinase activity. In mice, application of a 0.2% or 2% gel preparation of RK applied to mouse skin significantly increased the degree of skin whitening within one week of treatment. In contrast to the widely used flavoring properties of RK in perfumery and cosmetics, the skin-whitening potency of RK has been demonstrated in the present study. Based on our findings reported here, RK would appear to have high potential for use in the cosmetics industry.
    關聯: International Journal of Molecular Sciences 12(8), pp. 4819-4835
    显示于类别:[化妝品應用與管理系(所)] 期刊論文

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