Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale

doi:10.3390/ijms12084819

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/26663

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/26663

Title:	Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale
Authors:	Lin, Victor Chia-Hsiang Ding, Hsiou-Yu Kuo, Shiou-Yi Chin, Ling-Wei Wu, Jiumn-Yih Chang, Te-Sheng
Contributors:	化粧品科技研究所
Keywords:	B16 melanoma tyrosinase inhibition zebrafish melanogenesis Rheum officinale raspberry ketone
Date:	2011-10
Issue Date:	2013-06-03 15:52:45 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	Melanogenesis inhibition by raspberry ketone (RK) from Rheum officinale was investigated both in vitro in cultivated murine B16 melanoma cells and in vivo in zebrafish and mice. In B16 cells, RK inhibited melanogenesis through a post-transcriptional regulation of tyrosinase gene expression, which resulted in down regulation of both cellular tyrosinase activity and the amount of tyrosinase protein, while the level of tyrosinase mRNA transcription was not affected. In zebrafish, RK also inhibited melanogenesis by reduction of tyrosinase activity. In mice, application of a 0.2% or 2% gel preparation of RK applied to mouse skin significantly increased the degree of skin whitening within one week of treatment. In contrast to the widely used flavoring properties of RK in perfumery and cosmetics, the skin-whitening potency of RK has been demonstrated in the present study. Based on our findings reported here, RK would appear to have high potential for use in the cosmetics industry.
Relation:	International Journal of Molecular Sciences 12(8), pp. 4819-4835
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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