New Dimeric Analogs of 2-Aminodipyrido[L,2-A:3 ,2,-D] Imidazole : Synthesis And Interaction With DNA

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Title:	New Dimeric Analogs of 2-Aminodipyrido[L,2-A:3 ,2,-D] Imidazole : Synthesis And Interaction With DNA
Authors:	Ching-Shing Lee Yuichi Hashimoto Toshiharu Ohta Koichi Shudo Toshihiko Okamoto
Keywords:	intercalation 2-aminodipyrido〔1,2-a:3,2-d〕imidazole DNA melting temperature of DNA dimeric intercalator
Date:	1983
Issue Date:	2012-11-16 09:01:27 (UTC+8)
Abstract:	New dimeric analogs of intercalative 2-aminodipyrido - [1,2-a:3 ,2-d]imidazole (Glu-P-2), a potent muta-carcinogen isolated from a pyrolysate of L-glutamic acid, were synthesized. The high affinity of these compounds to DNA was demonstrated by fluorescence spectroscopic studies and by their effects in raising the melting temperature (TM) of DNA.
Relation:	嘉南學報 9, A37-A40 轉載自 Chem. Pharm. Bull. ,30(8),3046-3049
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.9 (1983)

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