The absorption and dsposition of ibuprofen was investigated in seven hemodialyzeduremic patients. Ibuprofen (400 mg) was orally administered to each patient 1 hr or 4 hr prior to hemodialysis. Uremic patients appeared to absorb ibuprofen at a slower rate as compared to nomal subjects. The hemodialysis systems used in this study yielded a mean extraction efficiency of 16.7% for ibuprofen, with a mean dialysis plasma clearance of 22.7 ml/min. The drug recovery resultiag from hemodialysis represented a small fraction of the ingested does of ibuprofen (<4%). The half-life of ibuprofen (1.3-1.9 hr) was not significantly altered by hemodialysis. Observations of extraction efficiency, drug recovery and half-life during dialysis suggested nondialyzability of ibuprofen, probably due to its extensive protein binding (~90%). Uremic patients may require a compara-tively longer time to achieve the treapeutic concentration attained in nomal volunteers.However, dosage adjustment is not required once a regimen is implemented in uremia.
