Pharmacokinetics of Ibuprofen During Hemodialysis

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 10期 (1984) > Item 310902800/25505

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標題:	Pharmacokinetics of Ibuprofen During Hemodialysis IBUPROFEN在洗腎過程中的藥品動力學研究
作者:	Tsan-Hwei Kuo
貢獻者:	藥學科
日期:	1984
上傳時間:	2012-09-12 16:29:20 (UTC+8)
摘要:	The absorption and dsposition of ibuprofen was investigated in seven hemodialyzeduremic patients. Ibuprofen (400 mg) was orally administered to each patient 1 hr or 4 hr prior to hemodialysis. Uremic patients appeared to absorb ibuprofen at a slower rate as compared to nomal subjects. The hemodialysis systems used in this study yielded a mean extraction efficiency of 16.7% for ibuprofen, with a mean dialysis plasma clearance of 22.7 ml/min. The drug recovery resultiag from hemodialysis represented a small fraction of the ingested does of ibuprofen (<4%). The half-life of ibuprofen (1.3-1.9 hr) was not significantly altered by hemodialysis. Observations of extraction efficiency, drug recovery and half-life during dialysis suggested nondialyzability of ibuprofen, probably due to its extensive protein binding (~90%). Uremic patients may require a compara-tively longer time to achieve the treapeutic concentration attained in nomal volunteers.However, dosage adjustment is not required once a regimen is implemented in uremia.
關聯:	嘉南學報 10期 : p.14-24
显示于类别:	[嘉南學報] 10期 (1984) [藥學系(所)] 期刊論文

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