Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E2 in the hypothalamus during pyrogen-induced fever in rabbits

doi:10.1016/j.ejphar.2009.11.060

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/25168

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/25168

標題:	Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E2 in the hypothalamus during pyrogen-induced fever in rabbits
作者:	Kuo-Feng Huang Wu-Tein Huang Kao-Chang Lin Mao-Tsun Lin Ching-Ping Chang
貢獻者:	休閒保健管理系
關鍵字:	Fever Lipopolysaccharide Glutamate Hydroxyl radical Interleukin-1 receptor antagonist Antipyresis Prostaglandin E2
日期:	2010-03
上傳時間:	2012-04-02 13:32:46 (UTC+8)
摘要:	The present study was attempted to determine whether interleukin-1 receptor antagonist (IL-1ra) pretreatment exerts its antipyresis by reducing organum vasculosum laminae terminalis (OVLT) release of glutamate, hydroxyl radicals and prostaglandin E2 in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and OVLT levels of glutamate, hydroxyl radicals, and prostaglandin E2. The rise in both the core temperature and OVLT glutamate, hydroxyl radicals and prostaglandin E2 could also be induced by intracerebroventricular injection of interleukin-1β. Pretreatment with an intracerebroventricular dose of IL-1ra significantly prevented the lipopolysaccharide or IL-1β-induced overproduction of glutamate, hydroxyl radicals, and prostaglandin E2 in OVLT of rabbit's brain. The febrile response caused by systemic administration of lipopolysaccharide or central injection of interleukin-1β could also be IL-1ra pretreatment-ameliorated. These results indicate that IL-1ra pretreatment may exert its antipyresis by inhibiting the glutamate–hydroxyl radicals–prostaglandin E2 pathways in the OVLT of rabbit's brain during lipopolysaccharide fever.
關聯:	European Journal of Pharmacology 629(1-2)：p.125-131
顯示於類別:	[休閒保健管理系(所)] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
99_37_j.pdf		671Kb	Adobe PDF	350	檢視/開啟
index.html		0Kb	HTML	1962	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....