Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E2 in the hypothalamus during pyrogen-induced fever in rabbits

doi:10.1016/j.ejphar.2009.11.060

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/25168

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Title:	Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E2 in the hypothalamus during pyrogen-induced fever in rabbits
Authors:	Kuo-Feng Huang Wu-Tein Huang Kao-Chang Lin Mao-Tsun Lin Ching-Ping Chang
Contributors:	休閒保健管理系
Keywords:	Fever Lipopolysaccharide Glutamate Hydroxyl radical Interleukin-1 receptor antagonist Antipyresis Prostaglandin E2
Date:	2010-03
Issue Date:	2012-04-02 13:32:46 (UTC+8)
Abstract:	The present study was attempted to determine whether interleukin-1 receptor antagonist (IL-1ra) pretreatment exerts its antipyresis by reducing organum vasculosum laminae terminalis (OVLT) release of glutamate, hydroxyl radicals and prostaglandin E2 in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and OVLT levels of glutamate, hydroxyl radicals, and prostaglandin E2. The rise in both the core temperature and OVLT glutamate, hydroxyl radicals and prostaglandin E2 could also be induced by intracerebroventricular injection of interleukin-1β. Pretreatment with an intracerebroventricular dose of IL-1ra significantly prevented the lipopolysaccharide or IL-1β-induced overproduction of glutamate, hydroxyl radicals, and prostaglandin E2 in OVLT of rabbit's brain. The febrile response caused by systemic administration of lipopolysaccharide or central injection of interleukin-1β could also be IL-1ra pretreatment-ameliorated. These results indicate that IL-1ra pretreatment may exert its antipyresis by inhibiting the glutamate–hydroxyl radicals–prostaglandin E2 pathways in the OVLT of rabbit's brain during lipopolysaccharide fever.
Relation:	European Journal of Pharmacology 629(1-2)：p.125-131
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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